diff --git a/src/tests/end2end/GpuMemorySynchronizationTests.cpp b/src/tests/end2end/GpuMemorySynchronizationTests.cpp
index e0a8db7be2..30b9c467ae 100644
--- a/src/tests/end2end/GpuMemorySynchronizationTests.cpp
+++ b/src/tests/end2end/GpuMemorySynchronizationTests.cpp
@@ -644,6 +644,11 @@ TEST_P(MultipleWriteThenMultipleReadTests, SeparateBuffers) {
 // buffer is composed of vertices, indices, uniforms and readonly storage. Data to be read in the
 // buffer in render pass depend on the write operation in compute pass.
 TEST_P(MultipleWriteThenMultipleReadTests, OneBuffer) {
+    // TODO(crbug.com/dawn/646): diagnose and fix this OpenGL ES failure.
+    // "Push constant block cannot be expressed as neither std430 nor std140. ES-targets do not
+    // support GL_ARB_enhanced_layouts."
+    DAWN_SKIP_TEST_IF(IsOpenGLES());
+
     // Create pipeline, bind group, and a complex buffer for compute pass.
     wgpu::ShaderModule csModule = utils::CreateShaderModuleFromWGSL(device, R"(
         [[block]] struct Contents {