diff --git a/src/dawn_native/ShaderModule.cpp b/src/dawn_native/ShaderModule.cpp
index 04949c572a..e21907d181 100644
--- a/src/dawn_native/ShaderModule.cpp
+++ b/src/dawn_native/ShaderModule.cpp
@@ -566,6 +566,10 @@ namespace dawn_native {
                                 }
                                 info->texture.sampleType = wgpu::TextureSampleType::Depth;
                             }
+                            if (imageType.ms && imageType.arrayed) {
+                                return DAWN_VALIDATION_ERROR(
+                                    "Multisampled array textures aren't supported");
+                            }
                             break;
                         }
                         case BindingInfoType::Buffer: {
diff --git a/src/tests/unittests/validation/RenderPipelineValidationTests.cpp b/src/tests/unittests/validation/RenderPipelineValidationTests.cpp
index 93c52bddfe..45a941c26b 100644
--- a/src/tests/unittests/validation/RenderPipelineValidationTests.cpp
+++ b/src/tests/unittests/validation/RenderPipelineValidationTests.cpp
@@ -501,33 +501,6 @@ TEST_F(RenderPipelineValidationTest, StorageBufferInVertexShaderNoLayout) {
     ASSERT_DEVICE_ERROR(device.CreateRenderPipeline(&descriptor));
 }
 
-// Test that a pipeline with defaulted layout may not have multisampled array textures
-// TODO(enga): Also test multisampled cube, cube array, and 3D. These have no GLSL keywords.
-// TODO(cwallez@chromium.org): Convert them to SPIRV ASM to remove the dependency on glslang.
-TEST_F(RenderPipelineValidationTest, MultisampledTexture) {
-    utils::ComboRenderPipelineDescriptor descriptor(device);
-    descriptor.layout = nullptr;
-    descriptor.cFragmentStage.module = fsModule;
-
-    // Base case works.
-    descriptor.vertexStage.module =
-        utils::CreateShaderModule(device, utils::SingleShaderStage::Vertex, R"(
-        #version 450
-        layout(set = 0, binding = 0) uniform texture2DMS texture;
-        void main() {
-        })");
-    device.CreateRenderPipeline(&descriptor);
-
-    // texture2DMSArray invalid
-    descriptor.vertexStage.module =
-        utils::CreateShaderModule(device, utils::SingleShaderStage::Vertex, R"(
-        #version 450
-        layout(set = 0, binding = 0) uniform texture2DMSArray texture;
-        void main() {
-        })");
-    ASSERT_DEVICE_ERROR(device.CreateRenderPipeline(&descriptor));
-}
-
 // Tests that strip primitive topologies require an index format
 TEST_F(RenderPipelineValidationTest, StripIndexFormatRequired) {
     constexpr uint32_t kNumStripType = 2u;
diff --git a/src/tests/unittests/validation/ShaderModuleValidationTests.cpp b/src/tests/unittests/validation/ShaderModuleValidationTests.cpp
index 2662de4166..be47d3cb6b 100644
--- a/src/tests/unittests/validation/ShaderModuleValidationTests.cpp
+++ b/src/tests/unittests/validation/ShaderModuleValidationTests.cpp
@@ -73,14 +73,83 @@ TEST_F(ShaderModuleValidationTest, NoChainedDescriptor) {
 }
 
 // Test that it is not allowed to use combined texture and sampler.
-// TODO(cwallez@chromium.org): Convert them to SPIRV ASM to remove the dependency on glslang.
 TEST_F(ShaderModuleValidationTest, CombinedTextureAndSampler) {
+    // SPIR-V ASM produced by glslang for the following fragment shader:
+    //
+    //   #version 450
+    //   layout(set = 0, binding = 0) uniform sampler2D tex;
+    //   void main () {}
+    //
+    // Note that the following defines an interface combined texture/sampler which is not allowed
+    // in Dawn / WebGPU.
+    //
+    //   %8 = OpTypeSampledImage %7
+    //   %_ptr_UniformConstant_8 = OpTypePointer UniformConstant %8
+    //   %tex = OpVariable %_ptr_UniformConstant_8 UniformConstant
     const char* shader = R"(
-        #version 450
-        layout (set = 0, binding = 0) uniform sampler2D texture;
-        void main() {
-        })";
+               OpCapability Shader
+          %1 = OpExtInstImport "GLSL.std.450"
+               OpMemoryModel Logical GLSL450
+               OpEntryPoint Fragment %main "main"
+               OpExecutionMode %main OriginUpperLeft
+               OpSource GLSL 450
+               OpName %main "main"
+               OpName %tex "tex"
+               OpDecorate %tex DescriptorSet 0
+               OpDecorate %tex Binding 0
+       %void = OpTypeVoid
+          %3 = OpTypeFunction %void
+      %float = OpTypeFloat 32
+          %7 = OpTypeImage %float 2D 0 0 0 1 Unknown
+          %8 = OpTypeSampledImage %7
+%_ptr_UniformConstant_8 = OpTypePointer UniformConstant %8
+        %tex = OpVariable %_ptr_UniformConstant_8 UniformConstant
+       %main = OpFunction %void None %3
+          %5 = OpLabel
+               OpReturn
+               OpFunctionEnd
+        )";
 
-    ASSERT_DEVICE_ERROR(
-        utils::CreateShaderModule(device, utils::SingleShaderStage::Fragment, shader));
+    ASSERT_DEVICE_ERROR(utils::CreateShaderModuleFromASM(device, shader));
+}
+
+// Test that it is not allowed to declare a multisampled-array interface texture.
+// TODO(enga): Also test multisampled cube, cube array, and 3D. These have no GLSL keywords.
+TEST_F(ShaderModuleValidationTest, MultisampledArrayTexture) {
+    // SPIR-V ASM produced by glslang for the following fragment shader:
+    //
+    //  #version 450
+    //  layout(set=0, binding=0) uniform texture2DMSArray tex;
+    //  void main () {}}
+    //
+    // Note that the following defines an interface array multisampled texture which is not allowed
+    // in Dawn / WebGPU.
+    //
+    //  %7 = OpTypeImage %float 2D 0 1 1 1 Unknown
+    //  %_ptr_UniformConstant_7 = OpTypePointer UniformConstant %7
+    //  %tex = OpVariable %_ptr_UniformConstant_7 UniformConstant
+    const char* shader = R"(
+               OpCapability Shader
+          %1 = OpExtInstImport "GLSL.std.450"
+               OpMemoryModel Logical GLSL450
+               OpEntryPoint Fragment %main "main"
+               OpExecutionMode %main OriginUpperLeft
+               OpSource GLSL 450
+               OpName %main "main"
+               OpName %tex "tex"
+               OpDecorate %tex DescriptorSet 0
+               OpDecorate %tex Binding 0
+       %void = OpTypeVoid
+          %3 = OpTypeFunction %void
+      %float = OpTypeFloat 32
+          %7 = OpTypeImage %float 2D 0 1 1 1 Unknown
+%_ptr_UniformConstant_7 = OpTypePointer UniformConstant %7
+        %tex = OpVariable %_ptr_UniformConstant_7 UniformConstant
+       %main = OpFunction %void None %3
+          %5 = OpLabel
+               OpReturn
+               OpFunctionEnd
+        )";
+
+    ASSERT_DEVICE_ERROR(utils::CreateShaderModuleFromASM(device, shader));
 }