diff --git a/src/dawn/tests/unittests/wire/WireBufferMappingTests.cpp b/src/dawn/tests/unittests/wire/WireBufferMappingTests.cpp
index 7ae8d130cd..d1d1cc8a76 100644
--- a/src/dawn/tests/unittests/wire/WireBufferMappingTests.cpp
+++ b/src/dawn/tests/unittests/wire/WireBufferMappingTests.cpp
@@ -335,7 +335,9 @@ TEST_F(WireBufferMappingReadTests, UnmapInsideMapReadCallback) {
 
 // Test that the MapReadCallback isn't fired twice the buffer external refcount reaches 0 in the
 // callback
-TEST_F(WireBufferMappingReadTests, DestroyInsideMapReadCallback) {
+// TODO(dawn:1621): Suppressed because the mapping handling still touches the buffer after it is
+// destroyed triggering an ASAN error.
+TEST_F(WireBufferMappingReadTests, DISABLED_DestroyInsideMapReadCallback) {
     wgpuBufferMapAsync(buffer, WGPUMapMode_Read, 0, kBufferSize, ToMockBufferMapCallback, nullptr);
 
     uint32_t bufferContent = 31337;