diff --git a/src/tests/end2end/MultisampledRenderingTests.cpp b/src/tests/end2end/MultisampledRenderingTests.cpp
index 3c17acdad9..0bd94a09a9 100644
--- a/src/tests/end2end/MultisampledRenderingTests.cpp
+++ b/src/tests/end2end/MultisampledRenderingTests.cpp
@@ -357,6 +357,9 @@ TEST_P(MultisampledRenderingTest, ResolveInAnotherRenderPass) {
 
 // Test doing MSAA resolve into multiple resolve targets works correctly.
 TEST_P(MultisampledRenderingTest, ResolveIntoMultipleResolveTargets) {
+    // TODO(dawn:462): Investigate backend validation failure.
+    DAWN_SKIP_TEST_IF(IsD3D12() && IsNvidia() && IsBackendValidationEnabled());
+
     wgpu::TextureView multisampledColorView2 =
         CreateTextureForOutputAttachment(kColorFormat, kSampleCount).CreateView();
     wgpu::Texture resolveTexture2 = CreateTextureForOutputAttachment(kColorFormat, 1);
@@ -428,6 +431,9 @@ TEST_P(MultisampledRenderingTest, ResolveOneMultisampledTextureTwice) {
 
 // Test using a layer of a 2D texture as resolve target works correctly.
 TEST_P(MultisampledRenderingTest, ResolveIntoOneMipmapLevelOf2DTexture) {
+    // TODO(dawn:462): Investigate backend validation failure.
+    DAWN_SKIP_TEST_IF(IsD3D12() && IsNvidia() && IsBackendValidationEnabled());
+
     constexpr uint32_t kBaseMipLevel = 2;
 
     wgpu::TextureViewDescriptor textureViewDescriptor;
@@ -465,6 +471,9 @@ TEST_P(MultisampledRenderingTest, ResolveIntoOneMipmapLevelOf2DTexture) {
 
 // Test using a level or a layer of a 2D array texture as resolve target works correctly.
 TEST_P(MultisampledRenderingTest, ResolveInto2DArrayTexture) {
+    // TODO(dawn:462): Investigate backend validation failure.
+    DAWN_SKIP_TEST_IF(IsD3D12() && IsNvidia() && IsBackendValidationEnabled());
+
     wgpu::TextureView multisampledColorView2 =
         CreateTextureForOutputAttachment(kColorFormat, kSampleCount).CreateView();