diff --git a/src/dawn_native/d3d12/UtilsD3D12.cpp b/src/dawn_native/d3d12/UtilsD3D12.cpp
index 98f056bc96..38479eba10 100644
--- a/src/dawn_native/d3d12/UtilsD3D12.cpp
+++ b/src/dawn_native/d3d12/UtilsD3D12.cpp
@@ -373,6 +373,10 @@ namespace dawn_native { namespace d3d12 {
     }
 
     void SetDebugName(Device* device, ID3D12Object* object, const char* prefix, std::string label) {
+        if (!object) {
+            return;
+        }
+
         if (label.empty() || !device->IsToggleEnabled(Toggle::UseUserDefinedLabelsInBackend)) {
             object->SetPrivateData(WKPDID_D3DDebugObjectName, strlen(prefix), prefix);
             return;
diff --git a/src/dawn_native/vulkan/UtilsVulkan.cpp b/src/dawn_native/vulkan/UtilsVulkan.cpp
index eb46180c4d..fd7a4ae8df 100644
--- a/src/dawn_native/vulkan/UtilsVulkan.cpp
+++ b/src/dawn_native/vulkan/UtilsVulkan.cpp
@@ -170,6 +170,10 @@ namespace dawn_native { namespace vulkan {
                       uint64_t objectHandle,
                       const char* prefix,
                       std::string label) {
+        if (!objectHandle) {
+            return;
+        }
+
         if (device->GetGlobalInfo().HasExt(InstanceExt::DebugUtils)) {
             VkDebugUtilsObjectNameInfoEXT objectNameInfo;
             objectNameInfo.sType = VK_STRUCTURE_TYPE_DEBUG_UTILS_OBJECT_NAME_INFO_EXT;
diff --git a/src/tests/end2end/DestroyTests.cpp b/src/tests/end2end/DestroyTests.cpp
index 19ef4b5925..b6889766cf 100644
--- a/src/tests/end2end/DestroyTests.cpp
+++ b/src/tests/end2end/DestroyTests.cpp
@@ -152,6 +152,18 @@ TEST_P(DestroyTest, TextureSubmitDestroySubmit) {
     ASSERT_DEVICE_ERROR(queue.Submit(1, &commands));
 }
 
+// Attempting to set an object label after it has been destroyed should not cause an error.
+TEST_P(DestroyTest, DestroyThenSetLabel) {
+    DAWN_TEST_UNSUPPORTED_IF(UsesWire());
+    std::string label = "test";
+    wgpu::BufferDescriptor descriptor;
+    descriptor.size = 4;
+    descriptor.usage = wgpu::BufferUsage::Uniform;
+    wgpu::Buffer buffer = device.CreateBuffer(&descriptor);
+    buffer.Destroy();
+    buffer.SetLabel(label.c_str());
+}
+
 DAWN_INSTANTIATE_TEST(DestroyTest,
                       D3D12Backend(),
                       MetalBackend(),
diff --git a/src/tests/end2end/DeviceLostTests.cpp b/src/tests/end2end/DeviceLostTests.cpp
index d0f092fbd7..3866a0747e 100644
--- a/src/tests/end2end/DeviceLostTests.cpp
+++ b/src/tests/end2end/DeviceLostTests.cpp
@@ -506,6 +506,18 @@ TEST_P(DeviceLostTest, FreeBindGroupAfterDeviceLossWithPendingCommands) {
     bg = nullptr;
 }
 
+// Attempting to set an object label after device loss should not cause an error.
+TEST_P(DeviceLostTest, SetLabelAfterDeviceLoss) {
+    DAWN_TEST_UNSUPPORTED_IF(UsesWire());
+    std::string label = "test";
+    wgpu::BufferDescriptor descriptor;
+    descriptor.size = 4;
+    descriptor.usage = wgpu::BufferUsage::Uniform;
+    wgpu::Buffer buffer = device.CreateBuffer(&descriptor);
+    LoseForTesting();
+    buffer.SetLabel(label.c_str());
+}
+
 DAWN_INSTANTIATE_TEST(DeviceLostTest,
                       D3D12Backend(),
                       MetalBackend(),