diff --git a/src/tests/end2end/BufferTests.cpp b/src/tests/end2end/BufferTests.cpp
index 2b0f10bc35..98f23878b7 100644
--- a/src/tests/end2end/BufferTests.cpp
+++ b/src/tests/end2end/BufferTests.cpp
@@ -635,6 +635,11 @@ TEST_P(CreateBufferMappedTests, LargeBufferFails) {
     // TODO(http://crbug.com/dawn/27): Missing support.
     DAWN_SKIP_TEST_IF(IsMetal() || IsOpenGL());
 
+    // TODO(http://crbug.com/dawn/241): Fails on NVIDIA cards when Vulkan validation layers are
+    // enabled becuase the maximum size of a single allocation cannot be larger than or equal to
+    // 4G on some platforms.
+    DAWN_SKIP_TEST_IF(IsVulkan() && IsNvidia() && IsBackendValidationEnabled());
+
     dawn::BufferDescriptor descriptor;
     descriptor.size = std::numeric_limits<uint64_t>::max();
     descriptor.usage = dawn::BufferUsage::MapRead | dawn::BufferUsage::CopyDst;